It is characterized to present weak or soft bones. However, this condition can also be related to renal diseases. Rickets is a condition produced due to a deficiency in vitamin D, calcium or phosphorus. This condition produces decreased calcium and increased phosphorus levels. Hypoparathyroidism is the result of inadequate parathyroid hormone production that occurs due to the presence of damage or removal of the parathyroid glands. Parathyroid hormone is responsible for the regulation of this metabolism in the kidneys.Įrgocalciferol is indicated for the treatment of hypoparathyroidism, refractory rickets, and familial hypophosphatemia. There is a time lag of 10 to 24 hours between the administration of vitamin D and the initiation of its action in the body due to the necessity of synthesis of the active metabolites in the liver and kidneys. Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal 4 tubules. Vitamin D metabolites promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization.

The first hydroxylation of ergocalciferol takes place in the liver (to 25-hydroxyvitamin D) and the second in the kidneys (to 1, 25-dihydroxyvitamin D). The in vivo synthesis of the major biologically active metabolites of vitamin D occurs in two steps. Ergocalciferol, also known as vaitamin D2 and calciferol, is a type of vitamin D found in food and used as a dietary supplement.

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